MK-571 sodium | 2692

MK-571 sodium is the sodium salt of the multidrug resistance protein-1 (MRP1) inhibitor MK-571 (Cat. No. 2691).

MK-571 sodium is a selective, CysLT1 receptor antagonist. It blocks the binding of leukotriene LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors but is ineffective at blocking LTC4 or LTD4activation of the recombinant human or murine CysLT2 receptors. MK-57 also acts as a specific inhibitor of multi-drug resistance protein-1 (MRP1).

2692 | MK-571 sodium DataSheet

Alternate Name/Synonyms: (E)-​3-​[[[3-​[2-​(7-​chloro-​2-​quinolinyl)ethenyl]phenyl][[3-​(dimethylamino)-​3-​oxopropyl]thio]methyl]thio]-​propanoic acid, sodium salt; L-660,711

Appearance: Off-white solid

Formulation: N/A

CAS Number: 115103-85-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₆ClN₂O₃S₂.Na

Molecular Weight: 537.07

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~10 mg/ml) or PBS (pH 7.2, ~10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A selective, CysLT1 receptor antagonist and multi-drug resistance protein-1 (MRP1) inhibitor

MDL Number: MFCD11114392

PubChem CID: 44322990

SMILES: CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)[O-].[Na+]

InChi: InChI=1S/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);/q;+1/p-1/b10-6+;/t26-;/m1./s1

InChi Key: XNAYQOBPAXEYLI-LQKFMROPSA-M