(+)-MK 801 Hydrogen Maleate | B2326

A potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux. It has been shown to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.

MK-801 is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux. It has been shown to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.

B2326 | (+)-MK 801 Hydrogen Maleate DataSheet

Alternate Name/Synonyms: 10,11-dihydro-5S-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate,Dizocilpine

Appearance: White solid

Formulation:

CAS Number: 77086-22-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₁₉NO₄

Molecular Weight: 337.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: ~6 mg/ml (H₂O) in 0,>20 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

MDL Number: MFCD0082465

PubChem CID: 6420042

SMILES: CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O

InChi: InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1

InChi Key: QLTXKCWMEZIHBJ-PJGJYSAQSA-N