MK-8745 | B1942

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

B1942 | MK-8745 DataSheet

Alternate Name/Synonyms: (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 885325-71-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₉ClFN₅OS

Molecular Weight: 431.91

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>18 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An Aurora-A specific inhibitor

MDL Number: N/A

PubChem CID: 11676373

SMILES: C1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F

InChi: InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)

InChi Key: YCRFPWKUUNKNDN-UHFFFAOYSA-N