ML133 Hydrochloride | B3097

ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC₅₀ values of 300 and 76 µM, respectively). ML133 inhibits the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.

ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC₅₀ values of 300 and 76 µM, respectively). ML133 inhibits the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.

B3097 | ML133 Hydrochloride DataSheet

Alternate Name/Synonyms: 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride

Appearance: Off-white solid

Formulation:

CAS Number: 1222781-70-5

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₁₉H₂₀ClNO

Molecular Weight: 313.82

Cell-Permeable?: True

Purity: ≥ 97%

Solubilities: ~10 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inward-rectifier potassium channel 2 (Kir2) inhibitor

MDL Number: MFCD20921521

PubChem CID: 44247466

SMILES: COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl

InChi: InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H

InChi Key: NGQIBUUFXDPHKT-UHFFFAOYSA-N