MLKL (phospho-S345) polyclonal Antibody | BS94021

MLKL (phospho-S345) polyclonal Antibody | BS94021 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Mouse

Application: IHC

Application Range: IHC:1:50-1:100

Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: MLKL (phospho-S345) polyclonal Antibody detects endogenous levels of MLKL protein only when phosphorylated at S345.

Molecular Weight: 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Mlkl, 9130019I15Rik, FLJ34389, hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain like pseudokinase, Mixed lineage kinase domain-like protein, Mlkl, MLKL,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: PI3K AKT signaling,MTOR signaling,