MLL3Antibody (N-term) [APR33461G]

MLL3Antibody (N-term) [APR33461G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1175 amino acids from the N-terminal region of human MLL3.

Cellular Localisation: Nucleus.

Molecular Weight: 541370

Clone: Polyclonal

Gene Name: KMT2C

Gene ID: 58508

Function: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738) . Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:24081332, PubMed:22266653) . Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332) .

Summary: Tissue Location: Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: IHC-P

Dilution: IHC-P--1:100~500

Synonyms: Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 2.1.1.43, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3