MLR-1023 | 2685

MLR-1023 is an allosteric activator of Lyn kinase (EC₅₀ = 63 nM). It reduces blood glucose levels without increasing insulin secretion in vivo. MLR-1023 does not activate peroxisome proliferator-activated α, d, and g receptors or glucagon-like peptide-1 receptors or inhibit dipeptidyl peptidase-4 (DPP-4) or -glucosidase enzyme activity.

MLR-1023 is an allosteric activator of Lyn kinase (EC₅₀ = 63 nM). It reduces blood glucose levels without increasing insulin secretion in vivo. MLR-1023 does not activate peroxisome proliferator-activated α, d, and g receptors or glucagon-like peptide-1 receptors or inhibit dipeptidyl peptidase-4 (DPP-4) or -glucosidase enzyme activity.

2685 | MLR-1023 DataSheet

Alternate Name/Synonyms: 5-(3-Methylphenoxy)-2(1H)-pyrimidinone; CID-39065; NSC314335; CP-26154; Tolimidone

Appearance: White solid

Formulation: N/A

CAS Number: 41964-07-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₀N₂O₂

Molecular Weight: 202.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml) or EtOH (~4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric Lyn kinase activator

MDL Number: MFCD00866900

PubChem CID: 39065

SMILES: CC1=CC(=CC=C1)OC2=CNC(=O)N=C2

InChi: InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

InChi Key: HJQILFPVRNHTIG-UHFFFAOYSA-N