MMP Substrate, Fluorogenic | B3262

MMP substrate, Fluorogenic is a widely used FRET substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, and MMP-16. Also acts as a substrate for Cathepsin D and Cathepsin E. Upon cleavage by MMPs, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

MMP substrate, Fluorogenic is a widely used FRET substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, and MMP-16. Also acts as a substrate for Cathepsin D and Cathepsin E. Upon cleavage by MMPs, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

B3262 | MMP Substrate, Fluorogenic DataSheet

Alternate Name/Synonyms: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (S)-N-((6S,9S,12S,15S,21S)-1-amino-12-(aminomethyl)-6-carbamoyl-1-imino-15-isobutyl-9,23-dimethyl-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-21-yl)-1-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)pyrrolidine-2-carboxamide, trifluoroacetate salt Mca-PLGL-Dpa-AR-NH2

Appearance: Lyophilized yellow solid

Formulation:

CAS Number: 140430-53-1

Structure Available?: Yes

Peptide sequence: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2

Salt Form: TFA

Molecular Formula: C₄₉H₆₈N₁₄O₁₅

Molecular Weight: 1093.15

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A fluorogenic MMP substrate

MDL Number:

PubChem CID: 71464411

SMILES: CC(C)CC(C(=O)NC(C1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-])C(C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)N)N)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C2CCCN2C(=O)CC3=CC(=O)OC4=C3C=CC(=C4)OC

InChi: InChI=1S/C49H68N14O15/c1-24(2)17-33(59-47(71)35-10-8-16-61(35)39(65)19-27-20-40(66)78-37-22-29(77-6)12-14-30(27)37)45(69)55-23-38(64)57-34(18-25(3)4)46(70)60-42(31-13-11-28(62(73)74)21-36(31)63(75)76)41(50)48(72)56-26(5)44(68)58-32(43(51)67)9-7-15-54-49(52)53/h11-14,20-22,24-26,32-35,41-42H,7-10,15-19,23,50H2,1-6H3,(H2,51,67)(H,55,69)(H,56,72)(H,57,64)(H,58,68)(H,59,71)(H,60,70)(H4,52,53,54)/t26-,32-,33+,34+,35+,41-,42?/m0/s1

InChi Key: OHJYDZUSNOGPHT-FSQMBESRSA-N