MMP26 polyclonal Antibody | BS60573

MMP26 polyclonal Antibody | BS60573 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Metalloproteinases (MMPs) are a family of proteins that are involved in the breakdown of the extracellular matrix during normal cellular events, including reproduction, tissue remodeling and embryonic development. MMP-26 (matrix metallopeptidase-26), also known as Endometase or Matrilysin-2, is a 261 amino acid metalloproteinase that is secreted as an inactive protein and is activated upon cleavage by extracellular proteinases. Expressed specifically in the placenta and uterus, MMP-26 hydrolyzes (and subsequently degrades) a variety of proteins such as Fibrinogen, Fibronectin, Vitronectin and collagen type IV (COL4) . MMP-26 binds zinc and calcium as cofactors and, unlike other MMP family members, lacks a conserved C-terminal domain. MMP-26 is widely expressed in a number of malignant tumor lines where it is thought to play an important role in tissue remodeling events that are associated with carcinogenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MMP26 polyclonal Antibody detects endogenous levels of MMP26 protein.

Molecular Weight: ~ 29 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Matrix metalloproteinase-26; MMP-26; Endometase; Matrilysin-2; MMP26

Immunogen: A synthetic peptide corresponding to residues in Human MMP26

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: