MMS21 Antibody | 5759

MMS21 Antibody | 5759 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Bovine: (80%)

Immunogen: MMS21 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human MMS21.
The immunogen is located within amino acids 170 - 220 of MMS21.

Research Area: Homeostasis

Tested Application: E, WB

Application: MMS21 antibody can be used for detection of MMS21 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 27 kDa
Observed: 30 kDa

Validation: N/A

Isoform: N/A

Purification: MMS21 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: MMS21 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: MMS21 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: MMS21 Antibody: NSE2, MMS21, ZMIZ7, C8orf36, E3 SUMO-protein ligase NSE2, MMS21 homolog, hMMS21

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: MMS21 Antibody: MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.