Mnk1 (I136) polyclonal Antibody | BS2133

Mnk1 (I136) polyclonal Antibody | BS2133 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB:1:500~1:1000 IHC: 1:50~1:200

Background: The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK) . The serine/threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Mnk1 (I136) polyclonal Antibody detects endogenous levels of Mnk1 protein.

Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; Mnk1; MKNK1; MNK1;

Immunogen: Synthetic peptide, corresponding to amino acids 102-154 of Human Mnk1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: