MNX1/HLXB9 polyclonal Antibody | BS65544

MNX1/HLXB9 polyclonal Antibody | BS65544 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Chicken,Cow,Rabbit,

Application: WB,

Application Range: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Background: The HB9 homeobox transcription factor regulates gene expression during embryonic development and also in specific adult tissues. HB9 gene mutations are implicated in Curriano syndrome, which is characterized by a triad consisting of a presacral tumor, sacral agenesis and anorectal malformation. In human bone marrow cells, HB9 expression directly correlates with CD34 expression. Furthermore, HB9 expression increases in CD34+ cells that are treated with IL-3 and granulocyte macrophage-colony-stimulating factor. Early in murine development, HB9 is expressed in pancreatic buds (dorsal and ventral) with subsequent expression in differentiating beta cells in the islets of Langerhans. The dorsal lobe of the pancreas fails to form in HB9 (-) mice; the resultant pancreas has smaller islets of Langerhans and less beta cells than normal pancreas. The HB9 gene is expressed in the human adult pancreas. In the developing vertebrate embryo, the HB9 gene plays an essential role in motor neuron differentiation. The motor columns of HB9 (-) mice are disorganized, lacking phrenic and abducens nerves and exhibiting intercostal nerve defects.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MNX1/HLXB9 polyclonal Antibody detects endogenous levels of MNX1/HLXB9 protein.

Molecular Weight: ~48kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HB9/HLXB9; HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant (Currarino triad) ; SCRA 1; SCRA1; SCRA1; HOXHB9.

Immunogen: KLH conjugated synthetic peptide derived from human MNX1/HLXB9 :131-230/401

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: