MOB1B Polyclonal Antibody | E-AB-18414

MOB1B Polyclonal Antibody | E-AB-18414 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: MATS 2, MATS2, MGC33910, Mob 1A, Mob 1B, MOB 4A, MOB kinase activator 1B, Mob1 homolog 1A, MOB1 Mps One Binder homolog B, MOB1 Mps one binder kinase activator like 1A, Mob1A, Mob1B, MOBKL 1A, MOBKL1A, MOL1A, Mps one binder kinase activator like 1A, Mps one binder kinase activator-like 1A, Protein Mob4A

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Signal Transduction

Background: The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 25 kDa

Molecular Weight(Observed): Refer to figures