Mouse Anti-Human ALK6 (BMP R1B) Antibody | 101-M176

Mouse Anti-Human ALK6 (BMP R1B) Antibody | 101-M176 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#3E12)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: BMPR1B; ALK6; ALK-6; CDw293

Isotype: IgG2

Application: WB, IHC

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: reombinant human ALK6 extracellular domain

Description: Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of heterooligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor IB (BMPRIB), also known as activin receptor-like kinase (ALK)6, is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGFβ family cytokines. In contrast to the TGFβ receptor system in which the type I receptor does not bind TGFβ in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPRIA, BMPRIB/ ALK6, and ActRI/ ALK2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPRIB binds BMP4 with high-affinity in solution and is a potent BMP4 antagonist in vitro. BMPRIB is expressed in various tissues during embryogenesis. In adult tissues, BMPRIB is only found in the brain. The extracellular domain of BMPRIB shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPRIB are highly conserved and share 98% amino acid sequence identity.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 658