Mouse Anti-Human TNFRSF1A Antibody | 101-M661

Mouse Anti-Human TNFRSF1A Antibody | 101-M661 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#5D31)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: TNFRSF1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55

Isotype: IgG1

Application: WB, N

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human TNFRSF1A EC domain

Description: Tumor Necrosis Factor Receptor-I (TNF RI, also known as p55/p60) is a high affinity receptor for TNF-alpha and -beta, potent mediators of multiple aspects of inflammatory immune responses. TNF RI, along with TNF RII, is a prototypic member of the TNF receptor superfamily and has been designated TNFRSF1 (A). All cell types are thought to express TNF RI, and most of the biological functions of TNF are mediated via TNF RI. Soluble forms of both TNF RI, generated as a result of proteolytic cleavage of the extracellular domain, has been detected in vivo in various biological fluids. The soluble TNF RI receptor can bind TNF with high affinity and functions as a TNF antagonist. TNF RI is thought to form homotrimers or oligomers upon ligand binding. The TNF RI extracellular domain includes four cysteine-rich repeats characteristic of the TNF receptor superfamily. TNF RI is capable of interacting with adaptor proteins upstream of NF-kB activation and contains a cytoplasmic "death domain" upstream of caspase-dependent apoptosis cascades.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 7132