Mouse Anti-Mouse VEGF-A, Blocking Antibody Antibody | mV1007m-m

Mouse Anti-Mouse VEGF-A, Blocking Antibody Antibody | mV1007m-m | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#MAB0705)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Vegfa; Vpf; Vegf; Vegf120; Vegf164; Vegf188

Isotype: IgG1

Application: N, WB

Detection Range: WB (mouse/human); Neutralization of VEGF: human, mouse

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse VEGF

Description: Mouse VEGF (or VEGF-A) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant murine VEGF (isoform 164) is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 164 amino acid polypeptide chains. The antibody blocks the binding of VEGF to VEGFR-2 ( mouse FLK) and therefore the initiation of signal transduction.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 22339