Mouse Csk Antibody (C-term) [APR17414G]

Mouse Csk Antibody (C-term) [APR17414G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This Mouse Csk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 398-431 amino acids from the C-terminal region of Mouse Csk.

Cellular Localisation: Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts

Molecular Weight: 50716

Clone: Polyclonal

Gene Name: Csk

Gene ID: 12988

Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity) .

Summary: Tissue Location: Ubiquitous, but most abundant in thymus and spleen, as well as in neonatal brain

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase MPK-2, p50CSK, Csk