Mouse Irgm1 Antibody (C-term) (Ascites) [AMM02393G]

Mouse Irgm1 Antibody (C-term) (Ascites) [AMM02393G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: M

Specificity: Purified His-tagged Mouse Irgm1 protein was used to produced this monoclonal antibody.

Cellular Localisation: Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane. Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes. Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomes

Molecular Weight: 46552

Clone: Monoclonal

Gene Name: Irgm1

Gene ID: 15944

Function: Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.

Summary: Tissue Location: Expressed in lung and primary macrophages.

Form: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000~16000

Synonyms: Immunity-related GTPase family M protein 1, 365-, Interferon-inducible GTPase 3, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47, LRG-47, Irgm1, Ifi1, Iigp3, Irgm