LBD
Mouse Nr5a2 Antibody (Center) [APR17831G]
- SKU:
- LBD-APR17831G
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Description
Mouse Nr5a2 Antibody (Center) [APR17831G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M, Rat
Specificity: This Mouse Nr5a2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-233 amino acids from the Central region of Mouse Nr5a2.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:O00482}.
Molecular Weight: 64020
Clone: Polyclonal
Gene Name: Nr5a2
Gene ID: 26424
Function: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity) . Activates the transcription of CYP2C38 (PubMed:30555544) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Nuclear receptor subfamily 5 group A member 2, Liver receptor homolog 1, LRH-1, Nr5a2, Lrh1