Mouse p21Cip1 Antibody (C-term S148) [APR32825G]

Mouse p21Cip1 Antibody (C-term S148) [APR32825G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse p21Cip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-154 amino acids from the C-terminal region of mouse p21Cip1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:P38936}. Nucleus

Molecular Weight: 17785

Clone: Polyclonal

Gene Name: Cdkn1a

Gene ID: 12575

Function: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex (PubMed:25329316) . Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity) . Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1