(Mouse) Rybp Antibody (Center) [ApR04809G]

(Mouse) Rybp Antibody (Center) [ApR04809G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Rybp antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 131-165 amino acids from the Central region of Mouse Rybp.

Cellular Localisation: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q8N488}. Nucleus, nucleoplasm. Note=Primarily found in the nucleus Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.

Molecular Weight: 24777

Clone: Polyclonal

Gene Name: Rybp

Gene ID: 56353

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365) . Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365) . May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365) . Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity) . May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297) . May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity) . May bind to DNA (PubMed:19170609) . May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911) .

Summary: Tissue Location: Expressed in embryonic stem cells.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: RING1 and YY1-binding protein, Death effector domain-associated factor, DED-associated factor, Rybp, Dedaf