Mouse Senp1 Antibody (Center) [APR31870G]

Mouse Senp1 Antibody (Center) [APR31870G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:Q9P0U3}. Cytoplasm. Note=Shuttles between cytoplasm and nucleus

Molecular Weight: 72511

Clone: Polyclonal

Gene Name: Senp1

Gene ID: 223870

Function: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:15923632, PubMed:29499132) . The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (By similarity) . Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity) . Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity) . Deconjugates SUMO2 from MTA1 (By similarity) . Deconjugates SUMO2 from MTA1 (By similarity) . Deconjugates SUMO1 from METTL3 (By similarity) . Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity) . Deconjugates SUMO1 from GPS2 (PubMed:29499132) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sentrin-specific protease 1, SUMO-1 protease 2, SuPr-2, Sentrin/SUMO-specific protease SENP1, Senp1, Supr2