(Mouse) Shh Antibody (C-term) [APR04775G]

(Mouse) Shh Antibody (C-term) [APR04775G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Shh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 397-431 amino acids from the C-terminal region of mouse Shh.

Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}

Molecular Weight: 47773

Clone: Polyclonal

Gene Name: Shh {ECO:0000312|MGI:MGI:98297}

Gene ID: 20423

Function: [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723) . Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (PubMed:8824192) . Both activities occur in the reticulum endoplasmic (PubMed:21357747) . Once cleaved, ShhC is degraded in the endoplasmic reticulum (PubMed:21357747) .

Summary: Tissue Location: Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs In the adult, expressed in lung and neural retina

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:1000

Synonyms: Sonic hedgehog protein, SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein 19 kDa product, Sonic hedgehog protein C-product, Sonic hedgehog protein 27 kDa product, Shh, Hhg1