(Mouse) Tdgf1 Antibody (N-term) [APR14744G]

(Mouse) Tdgf1 Antibody (N-term) [APR14744G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Tdgf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 37-70 amino acids from the N-terminal region of mouse Tdgf1.

Cellular Localisation: Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000250|UniProtKB:P13385}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000250|UniProtKB:P13385}

Molecular Weight: 18754

Clone: Polyclonal

Gene Name: Tdgf1

Gene ID: N/A

Function: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated Tdgf1 acts as a Nodal coreceptor in cis. Shedding of Tdgf1 by Tmem8a modulates Nodal signaling by allowing soluble Tdgf1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Summary: Tissue Location: Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:1000

Synonyms: Teratocarcinoma-derived growth factor, Cripto growth factor, Epidermal growth factor-like Cripto protein, Tdgf1, Cripto