(Mouse) Wdr5 Antibody [APR32957G]

(Mouse) Wdr5 Antibody [APR32957G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This Mouse Wdr5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the region of mouse Wdr5.

Cellular Localisation: Nucleus.

Molecular Weight: 36588

Clone: Polyclonal

Gene Name: Wdr5

Gene ID: 140858

Function: Contributes to histone modification (By similarity) . May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity) . As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity) . H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity) . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity) . May regulate osteoblasts differentiation (PubMed:11551928) . In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity) .

Summary: Tissue Location: Expressed in liver (at protein level) . Detected in brain, testis and kidney.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WD repeat-containing protein BIG-3, Wdr5, Big, Big3