MSK1 (phospho S376) polyclonal Antibody | BS94085

MSK1 (phospho S376) polyclonal Antibody | BS94085 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Rat

Application: WB ICC IHC IP

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: MSK1 (phospho S376) polyclonal Antibody detects endogenous levels of MSK1 protein only when phosphorylated at S376.

Molecular Weight: 90/80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: S6K-alpha-5, RSKL, RPS6KA5, 90 kDa ribosomal protein S6 kinase 5, EC 2.7.11.1, KS6A5, MGC1911, Mitogen and stress activated protein kinase 1, MSPK1, Nuclear Mitogen And Stress Activated Protein Kinase 1, Nuclear mitogen- and stress-activated protein kinase 1, Ribosomal protein S6 kinase 90kD polypeptide 5, Ribosomal protein S6 kinase 90kDa, Ribosomal protein S6 kinase 90kDa polypeptide 5, Ribosomal Protein S6 Kinase Alpha 5, Ribosomal protein S6 kinase alpha-5, RLPK, RPS6KA5, RSK Like Protein Kinase, RSK-like protein kinase, RSKL, S6K alpha 5, S6K-alpha-5,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser376 of human MSK1.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: