MSR1 polyclonal Antibody | BS6671

MSR1 polyclonal Antibody | BS6671 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:10 - 1:100

Background: The macrophage class A scavenger receptor (SR-A) mediates the uptake of modified low density lipoprotein (LDL) . The gene encoding human SR-A maps to chromosome 8 and gives rise to two alternatively spliced isoforms, type I and II (SR-AI and SR-AII), which were originally cloned from the phorbol ester-treated human monocytic cell line THP-1. Both isoforms contain six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V) and a type-specific C-terminal (VI) ) . Domain IV is essential for the trimerization of SR-A, whereas domain V is essential for the wide range of ligand recognition. SR-A is expressed in liver, placenta and brain. Both SR-AI and SR-AII mediate the uptake of LDLs in atherosclerotic lesions. A third isoform,

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MSR1 polyclonal Antibody detects endogenous levels of MSR1 protein.

Molecular Weight: ~ 63 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD204; MSR1; SCARA1

Immunogen: Recombinant full length Human MSR1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: