MSTN Antibody | 22-550

MSTN Antibody | 22-550 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 267-375 of human MSTN (NP_005250.1) .

Research Area: Cancer, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Signal Transduction

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: NCI-H460

Positive Control 2: U-937

Positive Control 3: BT-474

Positive Control 4: Mouse skeletal muscle

Positive Control 5: Mouse heart

Positive Control 6: Mouse liver

Molecular Weight: Observed: 43kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: MSTN, GDF8, MSLHP, Myostatin, GDF-8

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.