mTOR Inhibitor, WYE-132 | 2256

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo.

Wye-132 is a potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.19 nM). Displays >5000-fold selectivity over PI3Ks

2256 | mTOR Inhibitor, WYE-132 DataSheet

Alternate Name/Synonyms: 1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea; WYE-125132

Appearance: White solid

Formulation: N/A

CAS Number: 1144068-46-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₃N₇O

Molecular Weight: 519.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A sub-nanomolar potent mTOR inhibitor

MDL Number: MFCD16038851

PubChem CID: 25260757

SMILES: CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7

InChi: InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)

InChi Key: QLHHRYZMBGPBJG-UHFFFAOYSA-N