mTOR Inhibitor, WYE-23 | 2257

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.45 nM nM). Displays 1469-fold selectivity over PI3Kα (IC₅₀ = 661 nM).

Wye-23 is a potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.45 nM nM). Displays 1469-fold selectivity over PI3Kα (IC₅₀ = 661 nM).

2257 | mTOR Inhibitor, WYE-23 DataSheet

Alternate Name/Synonyms: 4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester

Appearance: White solid

Formulation: N/A

CAS Number: 1062169-46-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₂N₈O₄

Molecular Weight: 520.58

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A sub-nanomolar potent mTOR inhibitor

MDL Number: N/A

PubChem CID: 44233391

SMILES: COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)NC(=O)NC5CC5)N6CCOCC6

InChi: InChI=1S/C26H32N8O4/c1-37-26(36)33-10-8-20(9-11-33)34-24-21(16-27-34)23(32-12-14-38-15-13-32)30-22(31-24)17-2-4-18(5-3-17)28-25(35)29-19-6-7-19/h2-5,16,19-20H,6-15H2,1H3,(H2,28,29,35)

InChi Key: NQNFBVOZVJAWSQ-UHFFFAOYSA-N