MUC20 Antibody (C-term) [APR14363G]

MUC20 Antibody (C-term) [APR14363G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MUC20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-684 amino acids from the C-terminal region of human MUC20.

Cellular Localisation: Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane

Molecular Weight: 71982

Clone: Polyclonal

Gene Name: MUC20

Gene ID: 200958

Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF) -induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

Summary: Tissue Location: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules Detected in most of the male urogenital tract epithelia, with the exception of epididymis.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P-Leica, IF, FC

Dilution: WB--1:1000

Synonyms: Mucin-20, MUC-20, MUC20, KIAA1359