MVP polyclonal Antibody | BS90898

MVP polyclonal Antibody | BS90898 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:200

Background: Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: MVP polyclonal Antibody detects endogenous levels of MVP protein.

Molecular Weight: 99 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MVP, LRP, LRP, Lung resistance related protein, Lung resistance-related protein, Major vault protein, Major vault protein, rat, homolog of, MVP, MVP, testicular secretory protein Li 30, VAULT 1, VAULT1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: