MYH9 polyclonal Antibody | BS70320

MYH9 polyclonal Antibody | BS70320 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB 1:1000 - 1:2000 IHC 1:50 - 1:100

Background: Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regulate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa, IIb, and IIc, respectively (reviewed in 1) . While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATP hydrolysis, their cellular functions do not appear to be redundant and they have different subcellular distributions (2-5) . The carboxy-terminal tail domain of myosin II is important in isoform-specific subcellular localization (6) . Phosphorylation of myosin IIa at Ser1943 contributes to the regulation of breast cancer cell migration (7) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MYH9 polyclonal Antibody detects endogenous levels of MYH9 protein.

Molecular Weight: ~ 250 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MYH9;DFNA17;EPSTS;FTNS;MGC104539;MHA;NMHC-II-A;NMMHCA ; Myosin Iia;

Immunogen: Recombinant protein of human MYH9.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Notch Signaling,Nuclear Receptor Signaling,Cell Cycle Control G1 S Checkpoint,Epigenetic Writers and Erasers of Histone H3,Epigenetic Writers and Erasers of Histones H2A H2B and H4,