Na+ CP-pan (K1493) polyclonal Antibody | BS1328

Na+ CP-pan (K1493) polyclonal Antibody | BS1328 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC IF

Application Range: IHC: 1:50~1:200 IF: 1:50~1:200

Background: Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Sodium Channel-pan (K1493) polyclonal Antibody detects endogenous levels of Sodium Channel-pan protein.

Molecular Weight: ~ 230 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SCN2A; NAC2, SCN2A1, SCN2A2; Nav1.1; NAC1; SCN1; SCN1A; Nav1.2; SCN3A; KIAA1356, NAC3; Nav1.3; Nav1.4; SCN4A; Nav1.5; SCN5A; Nav1.6; SCN8A; MED; Nav1.7; SCN9A; NENA; Nav1.8; SCN10A; Nav1.9; hNaN; SCN11A; SCN12A; SNS2

Immunogen: Synthetic peptide, corresponding to amino acids 1470-1520 of Human SCN5A.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Actin Dynamics,Tumor Angiogenesis,Regulation of Microtubule Dynamics,Inhibition of Apoptosis,G Protein-coupled Receptors Signaling to MAPK Erk,