NAA10 Antibody (Center) [APR08602G]

NAA10 Antibody (Center) [APR08602G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NAA10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 135-167 amino acids from the Central region of human NAA10.

Cellular Localisation: Cytoplasm. Nucleus. Note=Also present in the free cytosolic and cytoskeleton-bound polysomes.

Molecular Weight: 26459

Clone: Polyclonal

Gene Name: NAA10

Gene ID: 8260

Function: Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052, PubMed:29754825, PubMed:20154145, PubMed:32042062) . Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222) . The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182) . Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488) . Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209) . Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256) . Acetylates HIST1H4A (PubMed:29754825) . Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821) .

Summary: Tissue Location: Ubiquitous..

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IF

Dilution: IF--1:25 WB--1:2000

Synonyms: N-alpha-acetyltransferase 10, 2.3.1.-, 2.3.1.88, N-terminal acetyltransferase complex ARD1 subunit homolog A, NatA catalytic subunit Naa10, NAA10, ARD1, ARD1A, TE2