NBN Antibody, KO Validated | 13-281

NBN Antibody, KO Validated | 13-281 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 435-754 of human NBN (NP_002476.2) .

Research Area: Cancer, Cell Cycle

Tested Application: WB

Application: WB: 1:500 - 1:1000

Specificiy: N/A

Positive Control 1: U-87MG

Positive Control 2: HeLa

Positive Control 3: HepG2

Positive Control 4: mouse liver

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 110kDa

Validation: Antibody is Knockout validated.

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: NIBRIN Antibody: ATV, NBS, P95, NBS1, AT-V1, AT-V2, Nibrin, Cell cycle regulatory protein p95

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.