NBQX disodium salt | 2759

NBQX is a potent, selective and competitive AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist. It targets both AMPA- and kainate-sensitive glutamate receptors (IC₅₀ = 0.15 and 4.8 µM, respectively). NBQX does not block the NMDA-sensitive glutamate receptor (IC₅₀ = ≥ 90 µM).

NBQX is a potent, selective and competitive AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist. It targets both AMPA- and kainate-sensitive glutamate receptors (IC₅₀ = 0.15 and 4.8 µM, respectively). NBQX does not block the NMDA-sensitive glutamate receptor (IC₅₀ = ≥ 90 µM).

2759 | NBQX disodium salt DataSheet

Alternate Name/Synonyms: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt

Appearance: Dark brown solid

Formulation: N/A

CAS Number: 479347-86-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₆N₄O₆SNa₂

Molecular Weight: 380.24

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: H₂O (~ 35 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An AMPA receptor antagonist

MDL Number: MFCD12910445

PubChem CID: 6098006

SMILES: C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])N=C(C(=N3)[O-])[O-].[Na+].[Na+]

InChi: InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;/q;2*+1/p-2

InChi Key: SVJKYIUJRJEABK-UHFFFAOYSA-L