NBR1 Antibody | 19-224

NBR1 Antibody | 19-224 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat, Monkey

Homology: N/A

Immunogen: Recombinant protein of human NBR1

Research Area: Autophagy, Cell Cycle

Tested Application: WB, IHC, IF, IP

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:100
IP: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: 293T

Positive Control 2: Mouse liver

Positive Control 3: Mouse kidney

Positive Control 4: Mouse brain

Positive Control 5: Rat liver

Positive Control 6: N/A

Molecular Weight: Observed: 107kDa/140kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: 1A1-3B, IAI3B, M17S2, MIG19, next to BRCA1 gene 1 protein, B-box protein, cell migration-inducing gene 19 protein, membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) , migration-inducing protein 19, neighbor of BRCA1 gene 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.