NCSTN Antibody (N-Term) [AMM06576G]

NCSTN Antibody (N-Term) [AMM06576G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, Rat

Specificity: This NCSTN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 99-133 amino acids from human NCSTN.

Cellular Localisation: Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Molecular Weight: 78411

Clone: Polyclonal

Gene Name: NCSTN

Gene ID: 23385

Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Summary: Tissue Location: Detected in brain (at protein level) (PubMed:10993067) . Widely expressed (PubMed:11396676)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:8000 WB--1:2000

Synonyms: Nicastrin, NCSTN, KIAA0253