ND4L polyclonal Antibody | BS1633

ND4L polyclonal Antibody | BS1633 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Mouse

Application: WB

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 4L (ND4L) is most likely a component of the hydrophobic protein fragment of Complex I. Mutations in the gene encodiing for ND4 are implicated in Leber hereditary optic neuropathy, a rare condition that can cause loss of central vision.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ND4L polyclonal Antibody detects endogenous levels of ND4L protein.

Molecular Weight: ~ 10 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3) ; NADH dehydrogenase subunit 4L; Mtnd4l; mt-Nd4l; Nd4l

Immunogen: A synthetic peptide corresponding to amino acids 80-97 of Mouse ND4L.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Insulin &Glucose Signaling,Cell Cycle G2 M DNA Damage Signaling Pathway,