BW
Nebulette Polyclonal Antibody | BS65465
- SKU:
- BW-BS65465
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- Usually ships in 5 working days
Description
Nebulette Polyclonal Antibody | BS65465 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat,
Application: WB,
Application Range: WB=1:500-2000
Background: Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy. Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Nebulette Polyclonal Antibody detects endogenous levels of Nebulette protein.
Molecular Weight: 116 kD
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Actin binding Z disk protein; bA56H7.1; LIM nebulette; LNEBL; NEBL; NEBL_HUMAN.
Immunogen: KLH conjugated synthetic peptide derived from human Nebulette:321-420/1014
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway: