Necrosis Inhibitor, Necrox-2 | 2228

A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.

Necrox-2 is a cell-permeable necrosis inhibitor that displays antioxidant property.

2228 | Necrosis Inhibitor, Necrox-2 DataSheet

Alternate Name/Synonyms: [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine

Appearance: Off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₂N₄O₄S₂

Molecular Weight: 516.67

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A necrosis inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: N/A

InChi: N/A

InChi Key: N/A