Necrosis Inhibitor, Necrox-5 | 2229

A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

Necrox-5 is a cell-permeable necrosis inhibitor that displays antioxidant property.

2229 | Necrosis Inhibitor, Necrox-5 DataSheet

Alternate Name/Synonyms: [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, dihydrochloride

Appearance: Light pink solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₁N₃O₃S₂ ∙ 2CH₄O₃S

Molecular Weight: 645.83

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (>10 mg/ml) or H₂O (>10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A necrosis inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: N/A

InChi: N/A

InChi Key: N/A