Necrostatin-1 | 1864

Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC₅₀ = 180 nM).

Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC₅₀ = 180 nM).

1864 | Necrostatin-1 DataSheet

Alternate Name/Synonyms: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1

Appearance: Yellow solid

Formulation: N/A

CAS Number: 4311-88-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₃N₃OS

Molecular Weight: 259.33

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A necroptosis inhibitor

MDL Number: MFCD00056916

PubChem CID: 2828334

SMILES: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

InChi: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)

InChi Key: TXUWMXQFNYDOEZ-UHFFFAOYSA-N