Nephrin Antibody (C-term) [AMM22112G]

Nephrin Antibody (C-term) [AMM22112G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This Nephrin monoclonal antibody is generated from mouse immunized with Nephrin recombinant protein.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.

Molecular Weight: 134742

Clone: Monoclonal

Gene Name: NPHS1

Gene ID: 4868

Function: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) .

Summary: Tissue Location: Specifically expressed in podocytes of kidney glomeruli

Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN