NEU2 Antibody (N-term) [APR17547G]

NEU2 Antibody (N-term) [APR17547G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NEU2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-50 amino acids from the N-terminal region of human NEU2.

Cellular Localisation: Cytoplasm, cytosol.

Molecular Weight: 42254

Clone: Polyclonal

Gene Name: NEU2

Gene ID: 4759

Function: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546) . Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha- (2->3) -sialylated GD1a and GT1B gangliosides over alpha- (2->8) - sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940) . Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha- (2->3) and alpha- (2->6) -sialyl linkages. Cleaves milk oligosaccharide alpha- (2->3) -sialyllactose, but is inactive toward alpha- (2->6) -sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha- (2->8) -linked Neu5Ac residues (PubMed:14613940) .

Summary: Tissue Location: Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P-Leica, WB, IF, FC

Dilution: IHC-P-Leica--1:250 WB--1:2000

Synonyms: Sialidase-2, Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2, NEU2