NEU4 Antibody (C-term) [APR30596G]

NEU4 Antibody (C-term) [APR30596G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This NEU4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-452 amino acids from the C-terminal region of human NEU4.

Cellular Localisation: [Isoform 1]: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1} Note=Predominantly associates with endoplasmic reticulum membranes Only a small fraction associates with mitochondrial and plasma membranes.

Molecular Weight: 51572

Clone: Polyclonal

Gene Name: NEU4

Gene ID: 129807

Function: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha- (2->3) -sialylated GD1a and GM3 and alpha- (2->8) -sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228) . Hydrolyzes poly- alpha- (2->8) -sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity) . May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691) . Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605) .

Summary: Tissue Location: [Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Sialidase-4, N-acetyl-alpha-neuraminidase 4, NEU4