Neurocan polyclonal Antibody | BS5819

Neurocan polyclonal Antibody | BS5819 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The lecticans are a family of chondroitin proteoglycans, including aggrecan, versican, neurocan and brevican, that contain a C-type lectin domain. Neurocan is a glycoprotein synthesized primarily by neurons, and its expression levels are highest during embryonic brain development and during the early postnatal period. Neurocan is a component of the extracellular matrix in the central nervous system that can bind to various other CNS matrix components, such as heparin, Tenascin-R, HB-GAM and NCAM, suggesting that it plays a role in axon guidance and neurite growth. Neurocan is a 1,257 amino acid, precursor protein in embryonic and neonatal rats that is proteolytically proc-essed in the adult CNS into an N-terminal fragment, which localizes to the cytoplasm of glial cells. Neurocan expression (including the re-expression of the neonatal isoform) increases significantly in adults in the glial scar resulting from cortical injury.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Neurocan polyclonal Antibody detects endogenous levels of Neurocan protein.

Molecular Weight: ~ 220 kDa (Full length), 140 kDa (Proteolytic variant)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3; NEUR

Immunogen: Synthetic peptide, corresponding to amino acids 440-485 of Human Neurocan.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A