NF-1 (Q34) polyclonal Antibody | BS2042

NF-1 (Q34) polyclonal Antibody | BS2042 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NF-1 (Q34) polyclonal Antibody detects endogenous levels of NFIA, NFIB, NFIC and NFIX protein.

Molecular Weight: ~ 47 (NFIB), 56 (NFIA, NFIC, NFIX) kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear factor 1 A-type; NF1-A; Nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein; NFIA; KIAA1439; Nuclear factor 1 B-type; NF1-B; Nuclear factor 1/B; Nuclear factor I/B; NF-I/B; NFI-B; TGGCA-binding protein; NFIB; Nuclear factor 1 C-type; NF1-C; Nuclear factor 1/C; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein; NFIC; NFI; Nuclear factor 1 X-type; NF1-X; Nuclear factor 1/X; Nuclear factor I/X; NF-I/X; NFI-X; TGGCA-binding protein; NFIX

Immunogen: Synthetic peptide, corresponding to the amino acids 20-60 of Human NF-1A.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A