NF-kB p65 Antibody | 13-954

NF-kB p65 Antibody | 13-954 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human NF-kB p65 (NP_068810.3) .

Research Area: Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Obesity, Signal Transduction, Transcription

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: NIH/3T3

Positive Control 2: Jurkat

Positive Control 3: BT-474

Positive Control 4: Mouse lung

Positive Control 5: Mouse liver

Positive Control 6: Rat lung

Molecular Weight: Observed: 65kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: RELA, p65, NFKB3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.